Publicado: Mier, Abril 17, 2019
Salud | Por Gertrudes Rodriquez

Tiny 3D printed human heart created by scientists in transplant breakthrough

Tiny 3D printed human heart created by scientists in transplant breakthrough

This article has been republished from materials provided by Tel Aviv University American Friends.

A transparent cup containing what Israeli scientists from Tel Aviv University say is the world's first 3D-printed, vascularised engineered heart, is seen during a demonstration at a laboratory in the university, Tel Aviv, Israel April 15, 2019.

The 3D printed heart is replete with cells, blood vessels, ventricles, and chambers.

The Israeli researchers are working on a cardiac patch meant to help patients recover from cardiac damage sustained by heart attacks.

A NY woman previously diagnosed with a rare bone cancer has received a 3D-printed sternum and rib cage produced by the CSIRO and Anatomics. But the technology that made it possible could eventually lead to the production of a human-sized organ.

A 3D printed heart made from human tissue is processed in Prof.

Until now, success has been limited to printing only simple tissues without blood vessels.

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University of Tel Aviv's Tal Dvir presents his team's 3D-printed heart. He worked with Prof. Their findings were published on April 15 in a study in Advanced Science.

The impact: Heart disease causes one in four deaths in the USA (about 610,000 people a year), and there's a shortage of heart donors for transplants, so 3D-printed hearts could help solve a major issue. For patients with late stage heart failure, a heart transplant is the only solution. The waiting list for patients in the U.S. can be as much as six months or more. A number of these patients will die while on the on the waiting list. "This heart is made from human cells and patient-specific biological materials". The study said that this allowed the "ink" to print out various cardiac patches or complex tissues structures that can be formed together to create a 3D heart. The team says that larger human hearts will require the same technology.

The Tel Aviv team extracted fatty tissue from patients and used this as the "ink" for the 3D printing, a blueprint with which to create tissue models. The team then separated the cellular and a-cellular material and reprogrammed all the cells to become pluripotent stem cells.

"The method we have developed will allow us in the future to print a heart of any size required from the human tissue of patients themselves, meaning that the body will not reject it", Dvir said. According to Dvir, the use of "native" patient-specific materials is crucial to successfully engineering tissues and organs.

The researchers are now planning on culturing the printed hearts in the lab and "teaching them to behave" like hearts, Dvir said.

Once this process is complete, the next step is to test the prints on animals. With this achievement, the researchers at Tel Aviv University theorised that organ printers could be available at hospitals as early as within 10 years.

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